What ultimately led to the demise of the plains indians during westward expansion

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The plains indians died because of disease and lost battles with Americans who believed it was their manifest destiny to control. [ Source: http://www.chacha.com/question/what-ultimately-led-to-the-demise-of-the-plains-indians-during-westward-expansion ]
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What ultimately led to the demise of the plains indians during we…?
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The plains indians died because of disease and lost battles with Americans who believed it was their manifest destiny to control.
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