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What is the difference between prednisone and prednisolone

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Prednisone is activated by the liver into prednisolone. For this reason, and because it is more easily absorbed, prednisolone is the drug of choice when hepatic disease or insufficiency is present. [ Source: http://www.chacha.com/question/what-is-the-difference-between-prednisone-and-prednisolone ]
More Answers to "What is the difference between prednisone and prednisolone"
What's the difference between Prednisone and Prednisolone?
http://www.pethealth101.com/arthritis_and_joint/corticosteroids.shtml
Prednisolone does not have to be converted by the liver to an active molecule, but prednisone does. For pets with liver failure, prednisolone is preferred.
Could you please explain if there is a difference between prednis...?
http://www.druginfonet.com/index.php?pageID=faq/new/DRUG_FAQ/Prednisone.htm
Dexamethasone is the generic form of decadron. Prednisone differs mainly in terms of potency. Prednisone is about 4-5 times as potent milligram for milligram as cortisol. Dexamethasone is about 20-25 times as powerful mg for mg. Prednisone ...
Do the weight differences between individual prednisone or salicy...?
http://www.dissolutiontech.com/DTresour/200505Articles/DT200505_QA.html
The calibration using these tablets typically does not produce results representing 100 % dissolution. Salicylic Acid tablets are non-disintegrating and the dissolution rate is dependent on the surface area exposed. The disintegrating predn...

Related Questions Answered on Y!Answers

What is the difference between Prednisone / Prednisolone used in cats?
Q: I am currently giving my cat steroids for inflammation in the mouth. While I don't know how long she will be on steroids, I wanted to know if there was a difference between the two steroids. I know long term use of steroids is not good for cats because it could cause diabetes and other complications. I am looking into other options to give my cat for the pain in her mouth. My cat is on prednisolone. Any help would be appreciated! Thanks!
A: Hi Elizabeth, I'll gladly answer your question to the best of my knowledge and experience.Predni-sone and PredNIS-OLONE do the same things, WHEN they get into the system. BUT -- the reason a good veterinarian will put a cat of pednisolone -- is an important difference metabolic difference between cats and us (and many other animals). A cat's digestive system. matabolic capabilities and liver functions are different than ours and other companion animals (like dogs)A cats' metabolic system cannot break down prednisone and get the benefit of the steroid. A cat's liver will "toss out" or eliminate most of a prednisone. Their digestive system will "see" Prednisone" as a hostile element and will elimate most of it. But Predisolone does not interact with our cat's digestive and metabolic system the way Prednisone does ours. The "bottom line" result is that if kitty receives say 5 mg of Prednisolone-- all of it will be available to do do what it's supoosed to do. But if one gives Kitty Prednisone -- kitty's body will reject most of it.Although I do not know what is going on, I do strongly believe (supported by research and the literature that you vet is prescribing the right drug...Also, don't worry as much about diabetes and other complications as you wrote...It is certainly possible, but if Kitty has inflamation that has not responded to other drugs; and if this is not a symptom/sign of another disorder -- your vet is doing the right thing......If kitty is heavy/overweight and any pred is used indiscrimatorly -- diabetes certainly can manifest.....But again remember that Pednilisone is NOT broken down and destroyed by the liver -- so unlike us and other animals -- the chance of it (administered correctly causing diabetes or other side-effects is not as high as when we think of ourselves and prednisone.......Our digestive and metabolic system and that of our cats is VERY different. Finally if you have a good vet -- he or she weighed the need to control the oral inflamation with the potential streriodical side-effects and likely made the right suggestion/decision./Dave GI hope this has helped.
What is the difference between Prednisone, prednisolone, and prednisolone acetate?
Q: What is the difference between all of these medications? and which one is more commonly used to treat mono and inflammation in humans (i.e. swollen tonsils)
A: Essentially, the only difference is the country of origin. Americans call it Prednisone; the English and Europeans call it prednisilone.Pred is a steroid and is VERY RARELY prescribed to treat active infections with inflammation. It actually can slow down the healing in an infective state.But for other conditions that are not infective: arthritis, asthma, pulmonary obstructive disease, exema..dampening down the inflammatory response of the body (that which is causing pain, swelling) is very helpful.
What is the difference between Prednisone and Prednisolone?
Q:
A: They have slightly different chemical structures. One is the metabolic precursor of the other.From http://ratguide.com/meds/endocrine_hormones/prednisone_prednisolone.php"Though prednisone and prednisolone are used in the same manner and equally as effective, they should not be confused with each other. Prednisone is activated by the liver into prednisolone. For this reason and because it is more easily absorbed, prednisolone is the drug of choice when hepatic disease or insufficiency is present."As you may know, they are both intermediate strength synthetic corticosteroids. "Prednisone and prednisolone are synthetic members of the glucocorticoid class of hormones. They are an intermediate acting, broad antiinflammatory, medication. They have less activity than dexamethasone or betamethasone, but exhibit greater activity than hydrocortisone."From http://patients.uptodate.com/topic.asp?file=adrenal/11356"Prednisone and prednisolone — Prednisone, the most widely used glucocorticoid, is prednisolone with an 11-keto instead of an 11-beta-hydroxy group. It is an inactive drug precursor that must be converted to prednisolone in the liver to become biologically active. Other modifications of prednisolone have been used to produce other glucocorticoids with varying biologic potency. Addition of a 6-alpha-methyl group to prednisolone yields methylprednisolone, which is about five times more potent than cortisol."See structures at http://patients.uptodate.com/image.asp?file=endo_pix/steroid_.htm
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